Dr. Arthur Siegel, from McClean Hospital in Boston, is a leading researcher on sudden death in long distance running and a consultant to IMMDA. He published his results of groundbreaking research in 2013 in the World Journal of Cardiovascular Disease (2013, 3, 17-20). His work gives the scientific evidence to back up the IMMDA recommendation.He concluded: "The increased risk for cardiac arrest and sudden death during marathon running occurs predominantly in middle-aged males with previously silent coronary heart disease. The use of pre-race low-dose aspirin is evidence- based by validated clinical paradigms to protect such runners from acute cardiac events during races triggered by high, even if transient, atherothrombotic risk."Similarly, research has been published regarding limiting caffeine to less than 200mg on the morning of a long run. The article: "Caffeine Reduces Myocardial Blood Flow During Exercise" by John P. Higgins, Kavita M. Babu in The American Journal of Medicine (Vol.126, Issue 8) http://www.amjmed.com/article/S0002-9343%2813%2900189-7/abstract?source=aemf also is scientific published evidence supporting our recommendations.Dr. Arthur Siegel, from McClean Hospital in Boston, is a leading researcher on sudden death in long distance running and a consultant to IMMDA. He published his results of groundbreaking research in 2013 in the World Journal of Cardiovascular Disease (2013, 3, 17-20). His work gives the scientific evidence to back up the IMMDA recommendation.He concluded: "The increased risk for cardiac arrest and sudden death during marathon running occurs predominantly in middle-aged males with previously silent coronary heart disease. The use of pre-race low-dose aspirin is evidence- based by validated clinical paradigms to protect such runners from acute cardiac events during races triggered by high, even if transient, atherothrombotic risk."Similarly, research has been published regarding limiting caffeine to less than 200mg on the morning of a long run. The article: "Caffeine Reduces Myocardial Blood Flow During Exercise" by John P. Higgins, Kavita M. Babu in The American Journal of Medicine (Vol.126, Issue 8) http://www.amjmed.com/article/S0002-9343%2813%2900189-7/abstract?source=aemf also is scientific published evidence supporting our recommendations.