13-7-2012: Sepsis: If you have any family member who is seriously ill in the hospital then you better print out these articles incase you may want to use them.
Reported July 13, 2012
New Sepsis Treatment Could Save Lives
(Ivanhoe Newswire) -- Every year 750,000 people are struck with severe sepsis. Researchers are looking into new treatments for this life threatening condition.
Sepsis is a serious medical condition caused by an overwhelming immune response to infection. Immune chemicals released into the blood to combat the infection trigger widespread inflammation, which leads to blood clots and leaky vessels. This results in impaired blood flow, which damages the body’s organs by depriving them of nutrients and oxygen. In severe cases, one or more organs fail. In the worst cases, blood pressure drops, the heart weakens and the patient spirals toward septic shock. Once this happens, multiple organs (lungs, kidneys, liver) may quickly fail and the patient can die.
In this study, researchers randomly assigned patients with severe sepsis to fluid resuscitation in the ICU with either 6% HES 130/0.4 or Ringer's acetate at a dose of up to 33 ml per kilogram of ideal body weight per day.
Of the 804 patients who underwent randomization, 798 were included in the modified intention-to-treat population. The two intervention groups had similar baseline characteristics. At 90 days after randomization, 201 of 398 patients assigned to HES 130/0.4 had died, as compared with 172 of 400 patients assigned to Ringer's acetate. 1 patient in each group had end-stage kidney failure.
In the 90-day period, 87 patients assigned to HES 130/0.4 were treated with renal-replacement therapy versus 65 patients assigned to Ringer's acetate. The results were supported by multivariate analyses, with adjustment for known risk factors for death or acute kidney injury at baseline.
Patients with severe sepsis assigned to fluid resuscitation with HES 130/0.4 had an increased risk of death at day 90 and were more likely to require renal-replacement therapy, as compared with those receiving Ringer's acetate.
Source: New England Journal of Medicine, July 2012
Vitamin B12: the forgotten micronutrient for critical care..................those with severe sepsis/septic shock.