"Dodelijke" rota virus....een genegeerde zeer effectieve behandeling
Rotavirus [diarrhoea !!] associated with blood group type A
Deadly Virus Linked to Your Blood Type
(Ivanhoe Newswire) – An estimated 500,000 people worldwide die from rotavirus every year. Rotavirus is a major intestinal pathogen that is the leading cause of severe dehydration and diarrhea in infants around the world.
Some strains of rotavirus find their way into the cells of the gastrointestinal tract by recognizing antigens associated with the type A blood group – histo-blood group antigen A— a finding that represents a new paradigm in understanding how this gut pathogen infects humans.
“The structure of a key part of a strain of the virus known as P provides a clue to how the virus infects human cells,” said Dr. B. V. Venkataram Prasad, professor of biochemistry and molecular biology at Baylor College of Medicine and the report's corresponding author. In strains of rotavirus that infect animals, the top of a spike on the virus attaches to the cell via a glycan (one of many sugars linked together to form complex branched-chain structures) with a terminal molecule of sialic acid. The same did not appear to be true of virus strains that infect humans, and scientists believed the human rotavirus strains were bound to glycans with an internal sialic acid molecule, but they did not know how this occurs.
In collaboration with the laboratory of Dr. Mary Estes, professor of molecular virology and microbiology at BCM, Prasad and his colleagues found that laboratory cells modified to express the histo-blood group antigen A were easily infected by this rotavirus strain. Cells that lacked this antigen were not easily infected.
An antibody to the histo-blood group antigen A blocked infection by the virus into human intestinal cells in culture.
“Further studies identified a second rotavirus strain P that uses the histo-blood group antigen as a receptor,” Prasad was quoted as saying.
The authors found humans infected with the P strain had type A blood, but more studies are needed to confirm the connection.
Larger populations of infected individuals need to be studied to determine if there is a clear association of these virus strains using histo-blood group antigens as a receptor," they said.
This finding raises questions about why humans developed different blood groups, Prasad said. It may be an evolutionary change that occurred after the pathogen first invaded human cells.
SOURCE: Nature, April, 2012
doi:10.1016/j.jep.2005.01.032 | How to Cite or Link Using DOI
Copyright © 2005 Elsevier Ireland Ltd All rights reserved.
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aDepartamento de Virologia, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde (CCS), Bloco I, Caixa Postal 68040, CEP 21941-590, Rio de Janeiro, Brazil
bInstituto de Biologia, Departamento de Botânica, Universidade Federal do Rio de Janeiro, CEP 21941-590, Rio de Janeiro, Brazil
cNúcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, CEP 21941-590, Rio de Janeiro, Brazil
Acute diarrhea, especially in children, is a very common disease with worldwide distribution and with a significant public health impact. Rotaviruses have been recognized as the major agents of diarrhea in infants and young children in developed as well as developing countries. In Brazil, diarrhea is one of the principal causes of death, mainly in the infant population. To fight diarrhea, traditional Brazilian medicine uses a great variety of plants. In this work, 12 medicinal plant species were screened for simian (SA-11) and human (HCR3) rotaviruses inhibition in vitro. At non-cytotoxic concentrations, the extracts from Artocarpus integrifolia L. (Moraceae) bark (480 μg/ml) and Spondias lutea L. (Anacardiaceae) leaves (160 μg/ml) had antiviral activity against both viruses. They showed inhibition of 99.2% and 97%, respectively, for human rotavirus, and 96.4% and 96.2% for simian rotavirus. The extracts from Myristica fragrans Houtt (Myristicaceae) seeds (160 μg/ml) and Spongias lutea bark (40 μg/ml) inhibited human rotavirus (90% and 82.2% inhibition, respectively), whereas the extracts from Anacardium occidentale L. (Anacardiaceae) leaves (4 μg/ml) and Psidium guajavaL. (Myrtaceae) leaves (8 μg/ml) showed activity only against simian rotavirus (82.2% and 93.8% inhibition, respectively). Our results indicate that the extracts of Artocarpus integrifolia, Myristica fragrans and Spongias lutea can be useful in the treatment of human diarrhea if the etiologic agent is a rotavirus.
Keywords: Antiviral activity; Rotavirus; Cytotoxicity; MA-104 cells; Diarrhea; Plant extracts