Epilepsie en metformin!!

SOURCE: The Journal of Visualized Experiments, February 2014


The effect of a ketogenic diet and epilepsy is by now well known.
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Reported February 21, 2014

Could Metabolism Be Linked to Epilepsy?


(Ivanhoe Newswire) – In a new study from Franciscan University in Steubenville, Ohio, researchers are exploring a possible link between metabolic defects and seizures. They found diet could influence vulnerability to seizures and identified a common diabetes drug that could help treat disorders like epilepsy.

Researchers made the connection by measuring fruit fly movement using web-cams and determined a drug commonly used to treat type 2 diabetes, called metformin, reduces the intensity of seizures.  Unlike other experiments which study behaviors from a collective number of fruit flies, this approach studied their behavior individually, which helped determine subtle differences in behavior and seizure alterations.

“This technique has allowed us to identify a number of metabolism-altering drugs that affect seizure susceptibility,” lead researcher Dr. Daniel Kuebler was quoted as saying. “It has opened up a new line of research looking at the effect dietary modifications have on seizure susceptibility.”

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SOURCE: The Journal of Visualized Experiments, February 2014